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Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease.
- Source :
-
Clinical chemistry [Clin Chem] 1996 Feb; Vol. 42 (2), pp. 298-302. - Publication Year :
- 1996
-
Abstract
- Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy age-matched controls by using a gas chromatographic-mass spectrometric technique. The mean CSF concentration and CSF/plasma concentration ratio of myo-inositol in AD were not significantly different from those determined in control subjects. Also, concentration profiles of other polyols were not significantly altered in AD. CSF and plasma myo-inositol concentrations were correlated in control subjects but not in AD subjects. However, a significant correlation between CSF and plasma 1,5-anhydrosorbitol (a polyol internal control) concentrations observed in control subjects was retained in AD subjects.
Details
- Language :
- English
- ISSN :
- 0009-9147
- Volume :
- 42
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8595727