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The effect of nutritional status on the cytokine and acute phase protein responses to elective surgery.
- Source :
-
Cytokine [Cytokine] 1995 May; Vol. 7 (4), pp. 380-8. - Publication Year :
- 1995
-
Abstract
- Weight loss and impaired nutritional status are associated with increased complications following surgery. This study aimed to assess the effect of nutritional status on the magnitude of the acute phase protein response, and determine if this is associated with changes in the magnitude of the related cytokine responses. Nineteen patients (10 wellnourished, 9 malnourished on the basis of body composition) undergoing major abdominal surgery were studied by frequent blood sampling in the early postoperative period. There was a significant reduction in the plasma C-reactive protein response in the malnourished group, but no difference between the groups in the responses of alpha 1-antitrypsin, alpha 1-acid glycoprotein, or in the trace elements iron or zinc, which reflect induction of ferritin and metallothionein. There was an early increase in IL-6, soluble receptors of TNF, and in IL-1 receptor antagonist in both groups, but no detectable increase in plasma IL-1 or TNF. There was no difference between the wellnourished and malnourished group for any of these markers of activation of the cytokine network. Weight loss is therefore associated with a reduction in aspects of the acute phase response, but this is due to impaired effectiveness rather than reduced magnitude of the cytokine response.
- Subjects :
- Acute-Phase Proteins analysis
Body Composition
Cachexia etiology
Cachexia immunology
Colectomy
Cytokines blood
Digestive System Neoplasms blood
Digestive System Neoplasms complications
Digestive System Neoplasms immunology
Digestive System Neoplasms surgery
Female
Gastrectomy
Humans
Hydrocortisone blood
Male
Pancreatectomy
Postoperative Period
Stress, Physiological blood
Stress, Physiological immunology
Stress, Physiological physiopathology
Trace Elements blood
Weight Loss
Acute-Phase Proteins biosynthesis
Acute-Phase Reaction
Cachexia physiopathology
Cytokines biosynthesis
Nutritional Status
Surgical Procedures, Operative
Subjects
Details
- Language :
- English
- ISSN :
- 1043-4666
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 8589269
- Full Text :
- https://doi.org/10.1006/cyto.1995.0048