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Renal medulla and bradykinin during the development of hypertension in SHR.
- Source :
-
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 1995 Jun-Jul; Vol. 22 (6-7), pp. 463-5. - Publication Year :
- 1995
-
Abstract
- 1. The long-term reduction in blood pressure following ACE inhibitor treatment in young spontaneously hypertensive rats (SHR) appears to depend on both the kidney and bradykinin. 2. The aim of this experiment was to examine the effects of ACE inhibition and bradykinin on renal morphology and blood pressure in SHR. 3. Between 6 and 10 weeks of age male SHR received one of four treatments: water (n = 26), ramipril (1 mg/kg per day; n = 24), ramipril (1 mg/kg per day) plus Hoe 140 (0.5 mg/kg per day; n = 25) or Hoe 140 (0.5 mg/kg per day; n = 25). 4. Renal medullary and cortical volumes were determined stereologically at 10 and 20 weeks of age. 5. After 4 weeks of treatment, ramipril reduced the size of the renal medulla while Hoe 140 increased medullary volumes compared to control. Ten weeks after treatment was stopped the renal medulla of the ramipril group had returned to normal, however, there was a persistent increase in medullary volume of both Hoe 140 treated groups. 6. Our results imply that bradykinin may influence the size of the renal medulla which may have important effects on the development of hypertension in SHR.
- Subjects :
- Adrenergic beta-Antagonists administration & dosage
Adrenergic beta-Antagonists pharmacology
Adrenergic beta-Antagonists therapeutic use
Angiotensin-Converting Enzyme Inhibitors administration & dosage
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Animals
Antihypertensive Agents administration & dosage
Antihypertensive Agents pharmacology
Antihypertensive Agents therapeutic use
Bradykinin administration & dosage
Bradykinin analogs & derivatives
Bradykinin pharmacology
Bradykinin therapeutic use
Bradykinin Receptor Antagonists
Disease Models, Animal
Hypertension drug therapy
Hypertension etiology
Kidney Cortex drug effects
Kidney Cortex metabolism
Kidney Medulla metabolism
Male
Ramipril administration & dosage
Ramipril pharmacology
Ramipril therapeutic use
Rats
Rats, Inbred SHR
Angiotensin-Converting Enzyme Inhibitors pharmacology
Blood Pressure drug effects
Bradykinin metabolism
Hypertension metabolism
Kidney Medulla drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0305-1870
- Volume :
- 22
- Issue :
- 6-7
- Database :
- MEDLINE
- Journal :
- Clinical and experimental pharmacology & physiology
- Publication Type :
- Academic Journal
- Accession number :
- 8582104
- Full Text :
- https://doi.org/10.1111/j.1440-1681.1995.tb02045.x