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Composite porosity of expanded polytetrafluoroethylene vascular prosthesis.
- Source :
-
Cardiovascular surgery (London, England) [Cardiovasc Surg] 1995 Oct; Vol. 3 (5), pp. 479-84. - Publication Year :
- 1995
-
Abstract
- Polytetrafluoroethylene (PTFE) prostheses were modified to produce two types of composite porosity PTFE grafts: type I--inner 60 microns/outer 20 microns and type II--inner 20 microns/outer 60 microns. These composite porosity PTFE designs were investigated for bleed through, graft healing and patency and compared with high porosity PTFE (60 microns) and standard PTFE (20 microns) grafts. The grafts were implanted into the carotid and femoral arteries of dogs and retrieved after 4, 12 and 18 weeks. Both composite porosity grafts showed significantly less bleed through than standard and high porosity grafts after reperfusion. In composite grafts, the 60-microns layer allowed fibrovascular tissue and histiocyte ingrowth from perigraft tissue, but the 20-microns layer did not. Neointima formation occurred earlier and endothelialization was more extensive in high porosity grafts, but seroma formation occurred in 25% of cases. In type I composite porosity grafts, smooth muscle cells of neointima migrated into the pores of the graft, providing a firmly anchored intima. Type II composite porosity grafts allowed better ingrowth of fibrovascular tissue at the outer layer from the perigraft tissue; however, endothelialization was not completed. Composite porosity grafts should be considered for evaluation in specific clinical situations.
- Subjects :
- Animals
Carotid Arteries pathology
Carotid Arteries surgery
Carotid Arteries ultrastructure
Cell Division
Dogs
Female
Femoral Artery pathology
Femoral Artery surgery
Femoral Artery ultrastructure
Graft Occlusion, Vascular pathology
Microscopy, Electron, Scanning
Permeability
Polytetrafluoroethylene
Porosity
Tunica Intima pathology
Tunica Intima ultrastructure
Blood Vessel Prosthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0967-2109
- Volume :
- 3
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cardiovascular surgery (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 8574529
- Full Text :
- https://doi.org/10.1016/0967-2109(95)94445-3