Back to Search
Start Over
Protection against papillomavirus with a polynucleotide vaccine.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1996 Feb; Vol. 173 (2), pp. 314-20. - Publication Year :
- 1996
-
Abstract
- Genital infections with human papillomavirus (HPV) are increasingly recognized as a significant source of human disease; HPV is now implicated in up to 90% of cervical carcinomas. Neutralizing antibodies against papillomaviruses recognize conformational epitopes formed when viral capsid proteins assemble into virions or virus-like particles. Immunization with plasmid DNA encoding the major viral capsid protein L1 was studied as a means of inducing neutralizing antibodies and protection against virus challenge. In a cottontail rabbit papillomavirus (CRPV) model, immunization with plasmid DNA encoding L1 elicited conformationally specific neutralizing antibodies and provided immunity against papilloma formation upon challenge with CRPV. Immunization with DNA encoding the capsid protein may provide a means of protecting humans against HPV and would simplify the production of multivalent vaccines by combining plasmids that encode the viral capsid proteins of different strains. This may be of importance given the multiplicity of HPV types capable of causing disease.
- Subjects :
- Animals
Antibodies, Viral analysis
Base Sequence
Capsid genetics
Capsid immunology
Cottontail rabbit papillomavirus genetics
DNA Primers chemistry
DNA, Viral genetics
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Immunity
Immunization
Molecular Sequence Data
Neutralization Tests
Papillomavirus Infections immunology
Papillomavirus Infections pathology
Plasmids genetics
Plasmids immunology
Rabbits
Skin Diseases pathology
Skin Diseases prevention & control
Skin Diseases virology
Tumor Virus Infections immunology
Tumor Virus Infections pathology
Cottontail rabbit papillomavirus immunology
DNA, Viral immunology
Papillomavirus Infections prevention & control
Papillomavirus Vaccines
Tumor Virus Infections prevention & control
Vaccines, Synthetic administration & dosage
Viral Vaccines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 173
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 8568291
- Full Text :
- https://doi.org/10.1093/infdis/173.2.314