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Pharmacokinetic and tissue distribution changes of adriamycin and adriamycinol after intravenous administration of adriamycin to alloxan-induced diabetes mellitus rats.
- Source :
-
Research communications in molecular pathology and pharmacology [Res Commun Mol Pathol Pharmacol] 1995 Aug; Vol. 89 (2), pp. 165-78. - Publication Year :
- 1995
-
Abstract
- The pharmacokinetic and tissue distribution changes of adriamycin (ADM) were investigated after intravenous (i.v.) administration of ADM, 16 mg/kg, to the control rats and alloxan-induced diabetes mellitus rats (AIDRs). After 1 min i.v. infusion of ADM, apparent 'constant' plasma levels of ADM were maintained from 2 to 12 h in the AIDRs, whereas the levels were detected only up to 3 h in the control rats. Adriamycinol was detected only up to 1 and 5 min for the control rats and AIDRs, respectively, with significantly higher levels in the AIDRs. In tissue distribution studies, the amount of ADM obtained from the heart, lung, stomach, liver, small intestine, large intestine, fat, and lymph nodes were significantly higher in the AIDRs than that in the control rats. The tissue to plasma ratios of the liver, fat, and muscle also increased significantly in the AIDRs than those in the control rats. The amount of adriamycinol obtained from the lung, kidney, and liver was significantly higher in the AIDRs. All 7 control rats survived longer than 48 h, however 7 out of 9 AIDRs died between 36-48 h after i.v. administration of ADM, suggesting that the i.v. doses. of ADM in diabetes mellitus patients may need to be modified if the present rat data could be extrapolated to human.
- Subjects :
- Animals
Antibiotics, Antineoplastic blood
Antibiotics, Antineoplastic urine
Diabetes Mellitus, Experimental blood
Diabetes Mellitus, Experimental urine
Doxorubicin blood
Doxorubicin urine
Injections, Intravenous
Male
Rats
Rats, Sprague-Dawley
Tissue Distribution
Antibiotics, Antineoplastic pharmacokinetics
Diabetes Mellitus, Experimental metabolism
Doxorubicin analogs & derivatives
Doxorubicin pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1078-0297
- Volume :
- 89
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Research communications in molecular pathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 8556271