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Effects of calcitonin gene-related peptide on acute and chronic effects of morphine.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1995 Nov; Vol. 52 (3), pp. 595-9. - Publication Year :
- 1995
-
Abstract
- Calcitonin gene-related peptide (CGRP), which has been observed in different parts of the nervous system, is known to modify pain sensitivity to different stimuli in rats and mice. The aim of this study was to investigate the possible interaction of CGRP with morphine on nociception in adult male NMRI mice after central administration of the peptide. CGRP (20 or 200 ng) did not itself modify pain sensitivity in the tail-flick test and did not affect the acute antinociceptive action of a single dose of morphine in the same test. However, CGRP suppressed the development of rapid tolerance to morphine in a dose-dependent manner, but had no action on the development of chronic tolerance to morphine and on manifestations of naloxone-precipitated withdrawal syndrome.
- Subjects :
- Animals
Behavior, Animal drug effects
Calcitonin Gene-Related Peptide administration & dosage
Dose-Response Relationship, Drug
Drug Tolerance
Injections, Intraventricular
Male
Mice
Mice, Inbred Strains
Naloxone pharmacology
Narcotic Antagonists pharmacology
Pain Measurement drug effects
Time Factors
Analgesics, Opioid pharmacology
Calcitonin Gene-Related Peptide pharmacology
Morphine pharmacology
Substance Withdrawal Syndrome psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 52
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 8545480
- Full Text :
- https://doi.org/10.1016/0091-3057(95)00146-n