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Effect of fatty acid treatment in cerebral malaria-susceptible and nonsusceptible strains of mice.
- Source :
-
The Journal of parasitology [J Parasitol] 1995 Dec; Vol. 81 (6), pp. 997-9. - Publication Year :
- 1995
-
Abstract
- Cerebral malaria-susceptible (C57BL/6) mice infected with Plasmodium berghei ANKA (PbA) developed low parasitemia and died from typical neurological symptoms between 8 to 10 days after infection. In contrast, nonsusceptible (BALB/c) mice developed high peripheral blood parasitemia and died 22-24 days later without neurological implications. Daily injections of fatty acids (FA) during the first 3 days after infection protected C57BL/6 mice from cerebral symptoms but had no effect on BALB/c mice. Thus, treated C57BL/6 mice developed hyperparasitemia and died 25 days after infection, like BALB/c mice. Red blood cells from C57BL/6 control mice were found to be more resistant to lysis by linoleic acid than those of BALB/c mice. Three days following infection with PbA, these differences disappeared. Treatment with FA prevented these changes. We concluded that the host's cells were altered soon after infection and that the nature and degree of alterations depended on the mouse strain, thus determining the eventual outcome of the infection. Likewise, the effects of FA might not be directed against the parasite but rather seem to act early after infection on these parasite-induced modifications of host cells.
- Subjects :
- Animals
Disease Susceptibility
Erythrocyte Membrane drug effects
Female
Hemolysis
Malaria mortality
Malaria physiopathology
Malaria therapy
Malaria, Cerebral mortality
Malaria, Cerebral physiopathology
Malaria, Cerebral therapy
Malaria, Cerebral veterinary
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Parasitemia mortality
Parasitemia physiopathology
Rodent Diseases mortality
Rodent Diseases physiopathology
Dietary Fats therapeutic use
Fatty Acids therapeutic use
Malaria veterinary
Parasitemia therapy
Plasmodium berghei pathogenicity
Rodent Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3395
- Volume :
- 81
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 8544078