A beta-lactamase from Serratia marcescens hydrolyzing the 2-carboxypenam T-5575.

Authors :: Matsumura N
Mitsuhashi S
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1995 Sep; Vol. 39 (9), pp. 2132-4.
Publication Year :: 1995
Abstract: A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-lactamase and has been classified as a group 1 cephalosporinase.

Subjects :: Anti-Bacterial Agents pharmacology
Hydrolysis
Isoelectric Focusing
Kinetics
Microbial Sensitivity Tests
Molecular Weight
Serratia marcescens chemistry
Serratia marcescens drug effects
beta-Lactamases isolation & purification
beta-Lactams
Anti-Bacterial Agents metabolism
Serratia marcescens enzymology
beta-Lactamases metabolism

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