Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization.

Authors :: Hodgson JE
Fosberry AP
Rawlinson NS
Ross HN
Neal RJ
Arnell JC
Earl AJ
Lawlor EJ
Source :: Gene [Gene] 1995 Dec 01; Vol. 166 (1), pp. 49-55.
Publication Year :: 1995
Abstract: Seven classes of Streptomyces clavuligerus mutants defective in clavulanic acid (CLA) biosynthesis have been identified and used to clone the chromosomal DNA encoding eight CLA biosynthetic genes. The complete sequences of three and the partial sequences of two of these biosynthetic genes are reported, together with their known or predicted functions.

Subjects :: Acetyltransferases genetics
Amino Acid Sequence
Base Sequence
Clavulanic Acid
Cloning, Molecular
DNA, Bacterial genetics
Genes, Bacterial
Genetic Complementation Test
Molecular Sequence Data
Promoter Regions, Genetic
Restriction Mapping
Ureohydrolases genetics
Anti-Bacterial Agents biosynthesis
Clavulanic Acids biosynthesis
Streptococcus genetics

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