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Effect of interferon-alpha therapy in a patient with common variable immunodeficiency and chronic Epstein-Barr virus infection.
- Source :
-
Pediatric hematology and oncology [Pediatr Hematol Oncol] 1995 Sep-Oct; Vol. 12 (5), pp. 489-93. - Publication Year :
- 1995
-
Abstract
- We report an 18-year-old boy with common variable immunodeficiency who presented with splenomegaly as well as left axillary and lateral cervical lymphadenopathy. Main laboratory investigations showed severe thrombocytopenia. Epstein-Barr virus (EBV) DNA was detected in the patient's throat-washing specimens and lymph node biopsy. Lymphocytes from the lymph node biopsy were also positive for EBV nuclear antigen. Serology for EBV and cytomegalovirus was negative. A therapeutic attempt with acyclovir did not influence the course of infection. Six months' treatment with human lymphoblastoid interferon-alpha (IFN alfa) brought about the normalization of clinical and hematologic conditions. Detection on throat-washing specimens carried out 1 year after therapy was negative. Our preliminary experience suggests that human lymphoblastoid IFN-alpha is a valid alternative in therapy of immunodeficient EB virus-infected patients.
Details
- Language :
- English
- ISSN :
- 0888-0018
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric hematology and oncology
- Publication Type :
- Academic Journal
- Accession number :
- 8519635
- Full Text :
- https://doi.org/10.3109/08880019509009480