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Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.
- Source :
-
Bollettino della Societa italiana di biologia sperimentale [Boll Soc Ital Biol Sper] 1995 May-Jun; Vol. 71 (5-6), pp. 125-32. - Publication Year :
- 1995
-
Abstract
- The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.
- Subjects :
- Animals
Combined Modality Therapy
Femoral Artery surgery
Hindlimb blood supply
Ischemia surgery
Male
Microscopy, Electron
Microsurgery
Polyethylene Glycols administration & dosage
Rats
Rats, Wistar
Reactive Oxygen Species metabolism
Superoxide Dismutase administration & dosage
Superoxide Dismutase pharmacokinetics
Ischemia drug therapy
Reperfusion Injury prevention & control
Superoxide Dismutase therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0037-8771
- Volume :
- 71
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Bollettino della Societa italiana di biologia sperimentale
- Publication Type :
- Academic Journal
- Accession number :
- 8519486