Stability of fluconazole in injectable solutions.

The stability of fluconazole 1 mg/mL in several injectable solutions at 25 degrees C over 72 hours was studied. Fluconazole 2 mg/mL was mixed in a 1:1 ratio with 5% dextrose injection, lactated Ringer's injection, potassium chloride 20 meq/L in 5% dextrose injection, heparin sodium 100 units/mL in 5% dextrose injection, theophylline 0.8 mg/mL in 5% dextrose injection, and morphine sulfate 0.5 mg/mL in 5% dextrose injection. Three 1-mL samples were taken from each admixture at 0, 6, 12, 24, 36, 48, and 72 hours and analyzed for fluconazole concentration by stability-indicating gas chromatography. Fluconazole 2 mg/mL was stable in potassium chloride plus 5% dextrose injection and in theophylline plus 5% dextrose injection for 72 hours. Fluconazole was stable in the other injectable solutions for 24 hours. The stability of theophylline, heparin, or morphine sulfate in the presence of fluconazole was not studied. Fluconazole was stable in potassium chloride 20 meq/L plus 5% dextrose injection and in theophylline 0.8 mg/mL plus 5% dextrose injection for 72 hours and stable in the other injectable solutions for 24 hours.