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Effects of digoxin and enalapril on heart period variability and response to head-up tilt in normal subjects.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1993 Jul 01; Vol. 72 (1), pp. 95-9. - Publication Year :
- 1993
-
Abstract
- To test the effects of digitalis and angiotensin-converting enzyme inhibition on the RR interval variability in an electrocardiogram, 20 normal subjects were given digoxin 0.25 mg, enalapril 10 mg, and placebo twice daily in a randomized, double-blind, crossover study. Continuous 24-hour electrocardiographic recordings obtained on day 5 of each treatment were analyzed and several time domain and power spectral measures of heart period variability were calculated. Digoxin markedly increased (up to 51%) indexes of vagal modulation of heart period without changing mean RR interval. Enalapril did not change any measure of heart period variability despite a modest hypotensive effect. To determine the effect of each treatment on the response to orthostatic stress, 10 subjects also underwent 15 minutes of 60 degrees head-up tilt; power spectra were calculated for 15 minutes at 0 degree and at 60 degrees of tilt. Neither active treatment affected the response to head-up tilt.
- Subjects :
- Adult
Autonomic Nervous System drug effects
Autonomic Nervous System physiology
Circadian Rhythm
Double-Blind Method
Electrocardiography, Ambulatory drug effects
Female
Head
Heart Rate physiology
Humans
Male
Middle Aged
Posture physiology
Digoxin pharmacology
Enalapril pharmacology
Heart Rate drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 72
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 8517437
- Full Text :
- https://doi.org/10.1016/0002-9149(93)90226-3