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Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1993 Jun 25; Vol. 36 (13), pp. 1880-92. - Publication Year :
- 1993
-
Abstract
- The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J. Med. Chem. 1992, 35, 3858). Modifications of the N-benzyl ring substitution were undertaken in an effort to mimic the Tyr4 residue of angiotensin II. Introduction of a p-carboxylic acid on the N-benzyl ring resulted in the discovery of compounds with nanomolar affinity for the receptor and good oral activity. SAR studies of these potent antagonists revealed that the thienyl ring, the (E)-acrylic acid, and the imidazole ring in addition to the two acid groups were important for high potency. Also, overlay comparisons of the parent diacid with both angiotensin II and a representative biphenylyltetrazole nonpeptide angiotensin II receptor antagonist are presented. The parent diacid analog, SK&F 108566 or (E)-3-[2-butyl-1-(4-carboxybenzyl)-1H-imidazole-5-yl]-2-[(2- thienyl)methyl]propenoic acid, is currently in clinical development for the treatment of hypertension.
- Subjects :
- Amino Acid Sequence
Angiotensin II antagonists & inhibitors
Animals
In Vitro Techniques
Models, Molecular
Molecular Sequence Data
Rabbits
Rats
Structure-Activity Relationship
Acrylates chemical synthesis
Acrylates pharmacology
Angiotensin Receptor Antagonists
Imidazoles chemical synthesis
Imidazoles pharmacology
Thiophenes
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 36
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 8515425
- Full Text :
- https://doi.org/10.1021/jm00065a011