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Biliary sludge and gallstones in pregnancy: incidence, risk factors, and natural history.
- Source :
-
Annals of internal medicine [Ann Intern Med] 1993 Jul 15; Vol. 119 (2), pp. 116-20. - Publication Year :
- 1993
-
Abstract
- Objective: To evaluate the incidence and symptoms of and risk factors for biliary sludge and gallstones during pregnancy and to assess the natural history of these conditions in the first year after delivery.<br />Design: Cohort study.<br />Patients: A total of 272 pregnant women recruited in the first trimester.<br />Measurements: Biliary sludge and gallstones were diagnosed using ultrasonography, both during pregnancy and after delivery. Predictors of the presence or disappearance of sludge and stones were examined.<br />Main Results: Overall, from the first trimester of pregnancy until the immediate postpartum period, 67 women were newly diagnosed with biliary sludge, and 6 women were newly diagnosed with gallstones. The respective incidence rates were 31% (95% Cl, 25% to 37%) and 2% (95% Cl, 0.2% to 4%). During pregnancy, 28% of women experienced biliary pain, which was associated only with presence of stones. After delivery, 92 women had sludge and 23 had stones. Sludge disappeared in 61% of these women (Cl, 50% to 73%) after a mean follow-up of 5 months, and stones disappeared in 28% of women (Cl, 10% to 46%) after 9.7 months of follow-up.<br />Conclusions: Biliary sludge occurred frequently during pregnancy but was generally asymptomatic and often disappeared spontaneously after delivery. Gallstones were much less frequent and were more likely to be associated with biliary pain.
- Subjects :
- Adult
Biliary Tract Diseases diagnostic imaging
Biliary Tract Diseases etiology
Cholelithiasis diagnostic imaging
Cholelithiasis etiology
Female
Humans
Incidence
Italy epidemiology
Postpartum Period
Pregnancy
Pregnancy Complications diagnostic imaging
Pregnancy Complications etiology
Prospective Studies
Risk Factors
Statistics as Topic
Ultrasonography
Biliary Tract Diseases epidemiology
Cholelithiasis epidemiology
Pregnancy Complications epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4819
- Volume :
- 119
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8512160
- Full Text :
- https://doi.org/10.7326/0003-4819-119-2-199307150-00004