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Spatial learning in an enclosed eight-arm radial maze in rats with sodium arsanilate-induced labyrinthectomies.
- Source :
-
Behavioral and neural biology [Behav Neural Biol] 1993 May; Vol. 59 (3), pp. 253-7. - Publication Year :
- 1993
-
Abstract
- Bilateral vestibular dysfunction was induced in Long-Evans male rats (n = 7) by intratympanic injections of sodium arsanilate (30 mg/side). Control rats (n = 6) received isotonic saline. Animals were tested for labyrinthine integrity by measuring air-righting and contact-righting reflexes. Rats were reduced to 85% of free-feeding body weight and tested in an enclosed 8-arm radial maze (1 trial/day over 10 days). Labyrinthectomized animals made significantly more errors (p < .001) and, unlike the controls, showed no significant improvement on this measure over acquisition training. These rats also made significantly more (p = 0.018) sequential same arm reentries and fewer sequential adjacent arm entries (p < .01). These findings demonstrate that information obtained from the vestibular system is very important in spatial learning in the rat.
Details
- Language :
- English
- ISSN :
- 0163-1047
- Volume :
- 59
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Behavioral and neural biology
- Publication Type :
- Academic Journal
- Accession number :
- 8503830
- Full Text :
- https://doi.org/10.1016/0163-1047(93)91034-k