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Isoproterenol stimulation of heme synthesis in cultures of human fetal liver from early gestation.
- Source :
-
Endocrinology [Endocrinology] 1977 May; Vol. 100 (5), pp. 1303-5. - Publication Year :
- 1977
-
Abstract
- The role of isoproterenol in the synthesis of heme associated with hemoglobin has been studied in primary cultures of human fetal liver. This drug (10-10M) stimulated the incorporation of 59Fe into heme associated with hemoglobin in cell cultures of livers obtained from human fetuses 8 to 10 weeks gestation but was inactive in cell cultures prepared from livers of older fetuses. Isoproterenol has its optimal activity at a much earlier time in gestation than that previously reported for testosterone or erythropoietin. The interpretation of these results is that there is present a cell population in human fetal liver early in gestation with the appropriate isoproterenol-receptors and capable of erythroid differentiation after exposure to the drug.
Details
- Language :
- English
- ISSN :
- 0013-7227
- Volume :
- 100
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 849725
- Full Text :
- https://doi.org/10.1210/endo-100-5-1303