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Identification of laudanosine, an atracurium metabolite, following a fatal drug-related shooting.
- Source :
-
Journal of analytical toxicology [J Anal Toxicol] 1993 Mar-Apr; Vol. 17 (2), pp. 117-9. - Publication Year :
- 1993
-
Abstract
- In a case involving a fatal shooting, toxicology tests on blood and urine demonstrated the presence of cocaine metabolites and a large amount of an unidentified compound. This compound was subsequently identified by mass spectral, gas chromatographic, and thin layer chromatographic tests as laudanosine, a metabolite of the skeletal muscle relaxant atracurium which was administered during emergency surgery. Identification was confirmed by comparison with commercially available standards. Because of the difficulty associated with isolating and chromatographing highly water-soluble compounds, recognition of this artifact is a useful tool in identifying these cases.
- Subjects :
- Adult
Atracurium blood
Atracurium urine
Chromatography, Thin Layer
Enzyme Multiplied Immunoassay Technique
Gas Chromatography-Mass Spectrometry
Humans
Isoquinolines blood
Isoquinolines urine
Male
Opium blood
Opium urine
Substance-Related Disorders
Atracurium analysis
Isoquinolines analysis
Opium analysis
Wounds, Gunshot
Subjects
Details
- Language :
- English
- ISSN :
- 0146-4760
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of analytical toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 8492564
- Full Text :
- https://doi.org/10.1093/jat/17.2.117