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Preparation, characterization and biological evaluation of cationic 99Tc/99mTc-dioxime complexes.

Authors :
Schwochau K
Linse KH
Steinmetz HJ
Astheimer L
Source :
Nuclear medicine and biology [Nucl Med Biol] 1993 Apr; Vol. 20 (3), pp. 317-24.
Publication Year :
1993

Abstract

New cationic 99Tc/99Tc complexes formed with various symmetrical and asymmetrical vicinal dioximes of different carbon chain length (C5-C8) were synthesized by reduction of pertechnetate with BH4-, separated by HPLC and characterized by i.r./u.v./vis. spectroscopy, FAB mass spectrometry and electrophoresis. All complexes studied are trisdioximes containing boron as a constituent. Their lipophilicity, as assessed by the octanol/saline partition coefficient, ranges over almost four orders of magnitude. The myocardial uptake of the 99mTc complexes in mice proves to be lower than expected. The organ distributions are distinctly affected by the lipophilicity, the position of the dioxime group and the introduction of a terminal methoxy group.

Details

Language :
English
ISSN :
0969-8051
Volume :
20
Issue :
3
Database :
MEDLINE
Journal :
Nuclear medicine and biology
Publication Type :
Academic Journal
Accession number :
8485491
Full Text :
https://doi.org/10.1016/0969-8051(93)90054-x