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Preparation, characterization and biological evaluation of cationic 99Tc/99mTc-dioxime complexes.
- Source :
-
Nuclear medicine and biology [Nucl Med Biol] 1993 Apr; Vol. 20 (3), pp. 317-24. - Publication Year :
- 1993
-
Abstract
- New cationic 99Tc/99Tc complexes formed with various symmetrical and asymmetrical vicinal dioximes of different carbon chain length (C5-C8) were synthesized by reduction of pertechnetate with BH4-, separated by HPLC and characterized by i.r./u.v./vis. spectroscopy, FAB mass spectrometry and electrophoresis. All complexes studied are trisdioximes containing boron as a constituent. Their lipophilicity, as assessed by the octanol/saline partition coefficient, ranges over almost four orders of magnitude. The myocardial uptake of the 99mTc complexes in mice proves to be lower than expected. The organ distributions are distinctly affected by the lipophilicity, the position of the dioxime group and the introduction of a terminal methoxy group.
- Subjects :
- Animals
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
Isotope Labeling
Mice
Mice, Inbred Strains
Molecular Structure
Oximes chemistry
Oximes pharmacokinetics
Radionuclide Imaging
Spectrometry, Mass, Fast Atom Bombardment
Tissue Distribution
Heart diagnostic imaging
Oximes chemical synthesis
Technetium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0969-8051
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nuclear medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 8485491
- Full Text :
- https://doi.org/10.1016/0969-8051(93)90054-x