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Expression of members of the heat-shock protein 70 family in the exoerythrocytic stages of Plasmodium berghei and Plasmodium falciparum.
- Source :
-
Parasitology research [Parasitol Res] 1993; Vol. 79 (2), pp. 109-13. - Publication Year :
- 1993
-
Abstract
- Exoerythrocytic stages of Plasmodium berghei cultured in HepG2-A16 hepatoma cells and those of P. falciparum in human hepatocytes transplanted under the kidney capsule of CB-17/ICr scid/scid mice were used to evaluate expression of heat-shock-related stress proteins. Although undetectable in the sporozoites, the expression of proteins similar in sequence of a heat-shock protein of 70 kDa and a glucose-regulated protein of 78 kDa was markedly induced in the hepatic stages of malaria parasites. Expression of these proteins in the exoerythrocytic stages of the malaria parasite warrants a systematic evaluation of their potential role in eliciting cellular immune responses directed against infected hepatocytes.
- Subjects :
- Animals
Anopheles parasitology
Erythrocytes
Fluorescent Antibody Technique
Heat-Shock Proteins analysis
Heat-Shock Proteins isolation & purification
Humans
Immunoblotting
Liver Transplantation
Mice
Mice, SCID
Molecular Weight
Plasmodium berghei pathogenicity
Plasmodium falciparum pathogenicity
Salivary Glands parasitology
Transplantation, Heterologous
Transplantation, Heterotopic
Tumor Cells, Cultured
Heat-Shock Proteins biosynthesis
Liver parasitology
Malaria physiopathology
Plasmodium berghei physiology
Plasmodium falciparum physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0932-0113
- Volume :
- 79
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Parasitology research
- Publication Type :
- Academic Journal
- Accession number :
- 8475027
- Full Text :
- https://doi.org/10.1007/BF00932255