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The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone.
- Source :
-
Pharmacological research [Pharmacol Res] 1993 Feb-Mar; Vol. 27 (2), pp. 165-72. - Publication Year :
- 1993
-
Abstract
- The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone (0.01-10 microM) caused a concentration-dependent inhibition of both the NO2- production and the anti-aggregating activity of the cells. The inhibitory effect of dexamethasone was blocked by the glucocorticoid antagonist RU 38486. These data suggested that the protective effect of glucocorticoids in endotoxin-induced hypotension and their immunosuppressive action may both depend, at least in part, on the inhibition by these steroids of the induction of the nitric oxide synthase.
Details
- Language :
- English
- ISSN :
- 1043-6618
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 8474960
- Full Text :
- https://doi.org/10.1006/phrs.1993.1016