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The behavioral syndrome induced by adreno corticotropic hormone in rats is prevented by Ca++ channel blockade.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 1993 Feb; Vol. 16 (2), pp. 83-6. - Publication Year :
- 1993
-
Abstract
- The most typical signs (stretchings, yawnings, penile erections, excessive grooming) of the behavioral syndrome induced in rats by the intracerebroventricular administration of ACTH- (1-24) (4 micrograms/rat) were dose-dependently antagonized by the intraperitoneal injection of the selective Ca++ channel inhibitor, nicardipine (dose range: 0.1-1 mg/kg). These data suggest that the influx of Ca++ into target neurons is a step of key importance for the occurrence of ACTH-induced behavioral signs, and that Ca++ may play the role of second intracellular messenger for the behavioral effects of melanocortins.
Details
- Language :
- English
- ISSN :
- 0391-4097
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 8463553
- Full Text :
- https://doi.org/10.1007/BF03347653