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Metabolism in vitro of radioiodinated N-isopropyl-p-iodoamphetamine by isolated hepatocytes.
- Source :
-
Nuclear medicine and biology [Nucl Med Biol] 1993 Jan; Vol. 20 (1), pp. 49-56. - Publication Year :
- 1993
-
Abstract
- An in vitro technique for the determination of radiopharmaceutical metabolism has been developed using isolated hepatocytes. Radioiodinated N-isopropyl-p-iodoamphetamine (IMP; iofetamine, USP) was employed a model tracer in these studies because its labeled metabolites are well-characterized. Hepatocytes isolated from the rat and human produced labeled metabolites in vitro for up to 4 h in a manner similar to that reported for humans in vivo. Identical metabolites were generated by all cell types investigated, but the rate of metabolism differed (rat >> human; female > male; fresh > frozen). The utility of this methodology for the preclinical evaluation of potential radiopharmaceuticals is described.
Details
- Language :
- English
- ISSN :
- 0969-8051
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nuclear medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 8461879
- Full Text :
- https://doi.org/10.1016/0969-8051(93)90135-h