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Prevention of symptomatic patent ductus arteriosus with ethamsylate in babies treated with exogenous surfactant.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 1993 Jan-Feb; Vol. 13 (1), pp. 2-7. - Publication Year :
- 1993
-
Abstract
- Some trials in premature infants with respiratory distress syndrome have shown an increased incidence of patent ductus arteriosus after exogenous surfactant therapy. The effect of prophylactic ethamsylate on patent ductus arteriosus after intratracheal administration of a single dose of porcine surfactant preparation (Curosurf, 2.5 ml/kg) was studied in a group of 20 preterm infants with severe respiratory distress syndrome. Gestational age of the patients was 29.2 +/- 2.5 weeks (mean +/- SD), and birth weight was 1158 +/- 319 gm. Ethamsylate (12.5 mg/kg) was given prophylactically within the first 4 hours of life followed by 6-hourly doses for 4 days. Hemodynamically significant patent ductus arteriosus occurred more frequently in the untreated group (8 of 10) than in the ethamsylate group (2 of 10) (p < 0.02). No acute adverse effects were attributed to the therapy. This preliminary experience suggests that ethamsylate, an inhibitor of prostaglandin biosynthesis, could be useful in reducing the incidence of patent ductus arteriosus in very low birth weight infants treated with exogenous surfactant.
- Subjects :
- Ductus Arteriosus, Patent chemically induced
Female
Humans
Infant, Newborn
Infant, Premature, Diseases chemically induced
Male
Prospective Studies
Pulmonary Gas Exchange
Pulmonary Surfactants adverse effects
Pulmonary Surfactants therapeutic use
Respiratory Distress Syndrome, Newborn drug therapy
Respiratory Distress Syndrome, Newborn physiopathology
Treatment Outcome
Biological Products
Ductus Arteriosus, Patent prevention & control
Ethamsylate therapeutic use
Infant, Premature, Diseases prevention & control
Phospholipids
Subjects
Details
- Language :
- English
- ISSN :
- 0743-8346
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 8445442