Back to Search
Start Over
Interference of immune globulin with measles and rubella immunization.
- Source :
-
The Journal of pediatrics [J Pediatr] 1993 Feb; Vol. 122 (2), pp. 204-11. - Publication Year :
- 1993
-
Abstract
- Passively acquired antibody may interfere with the active antibody response to live viral vaccines such as measles and rubella. To evaluate the duration of this inhibitory effect, we measured the measles and rubella antibody responses of Apache children immunized with measles, mumps, and rubella vaccine at varying intervals after administration of an immune globulin termed bacterial polysaccharide immune globulin (BPIG). This specific immune globulin contained measles and rubella antibody titers similar to those in standard intramuscularly and intravenously administered immune globulins. Antibody responses to measles vaccine were inhibited for up to 5 months after a BPIG dose of 80 mg IgG per kilogram of body weight, but responses to rubella vaccine were inhibited for only 2 months. Most children who had a decreased measles antibody response to primary measles, mumps, and rubella immunization given 1 1/2 to 4 months after BPIG administration responded to a booster immunization given 6 months after their last BPIG dose. We conclude that high doses of immune globulin (> 10 mg/kg) may inhibit the antibody response to measles for more than 3 months. We propose that the interval between administration of immune globulin and measles and rubella immunization be adjusted on the basis of the dose of immune globulin.
- Subjects :
- Cohort Studies
Double-Blind Method
Humans
Immunization Schedule
Immunization, Secondary
Infant
Measles Vaccine administration & dosage
Mumps Vaccine pharmacology
Mumps virus immunology
Placebos
Time Factors
Vaccination
Antibodies, Viral biosynthesis
Bacterial Vaccines pharmacology
Haemophilus Vaccines
Immunoglobulins pharmacology
Measles Vaccine pharmacology
Measles virus immunology
Rubella Vaccine pharmacology
Rubella virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 122
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 8429432
- Full Text :
- https://doi.org/10.1016/s0022-3476(06)80114-9