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[Studies on tissue concentration of tegafur, 5-fluorouracil, uracil after UFT administration together with the study of microangiography of colorectal cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1993 Jan; Vol. 20 (1), pp. 125-30. - Publication Year :
- 1993
-
Abstract
- In order to elucidate the effect of tumor vascularity on a various regimens concentration in tumor tissue, correlation among tegafur, 5-fluorouracil (5-FU), uracil concentrations in tissue and the microangiography were examined in 27 patients with colorectal cancer after preoperative administration of UFT (400 mg/day for 7 days). The concentrations of tegafur, 5-FU and uracil in tumor were higher than those in normal tissue (p < 0.01). There was no definite correlation between tissue concentration in each regimen and the extra or intramural vascular changes. A significant high concentration of 5-FU was found in the protuberant cancer and the ulcerative cancer with horizontal growth than that in the ulcerative cancer with vertical growth (p < 0.05). The present study indicates that the vascular changes within a tumor and the vascular pattern of tumor may be a contributing factor affecting the tissue concentration in the regimens.
- Subjects :
- Aged
Antineoplastic Agents administration & dosage
Chromatography, High Pressure Liquid
Colorectal Neoplasms drug therapy
Colorectal Neoplasms metabolism
Female
Gas Chromatography-Mass Spectrometry
Humans
Male
Middle Aged
Tegafur administration & dosage
Tegafur pharmacokinetics
Uracil administration & dosage
Uracil pharmacokinetics
Antineoplastic Agents pharmacokinetics
Antineoplastic Combined Chemotherapy Protocols
Colorectal Neoplasms blood supply
Fluorouracil analysis
Tegafur analysis
Uracil analysis
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 8422176