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Implications of positive surgical margins.
- Source :
-
The Laryngoscope [Laryngoscope] 1993 Jan; Vol. 103 (1 Pt 1), pp. 64-8. - Publication Year :
- 1993
-
Abstract
- The recently concluded Head and Neck Intergroup trial tested the addition of three courses of cis-platinum containing chemotherapy to standard treatment of surgery and postoperative radiotherapy for patients with advanced operable squamous cell carcinoma of the head and neck. Only patients with negative surgical margins were eligible for the trial. One hundred twelve patients with positive surgical margins were dropped from the trial but continued to be followed. These patients received a variety of treatments. Positive surgical margins were most often seen in nonglottic primaries and with increasing frequency as the N stage increased. Patients with positive margins who achieved a complete clinical response to subsequent treatment had a median survival of 33.8 months vs. 9.1 months for those with less than a complete clinical response. The addition of chemotherapy did not significantly alter the median survival of the positive margin patients.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell radiotherapy
Carcinoma, Squamous Cell secondary
Chemotherapy, Adjuvant
Cisplatin administration & dosage
Cisplatin therapeutic use
Combined Modality Therapy
Female
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms radiotherapy
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Remission Induction
Survival Rate
Treatment Failure
Treatment Outcome
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell surgery
Head and Neck Neoplasms pathology
Head and Neck Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0023-852X
- Volume :
- 103
- Issue :
- 1 Pt 1
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 8421422
- Full Text :
- https://doi.org/10.1288/00005537-199301000-00012