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Search for a genetic event in monozygotic twins discordant for schizophrenia.
- Source :
-
Psychiatry research [Psychiatry Res] 1993 Jul; Vol. 48 (1), pp. 27-36. - Publication Year :
- 1993
-
Abstract
- When monozygotic twins are discordant for the diagnosis of schizophrenia, this discordance has been traditionally attributed to environmental factors acting upon a genome susceptible for the schizophrenia phenotype. The study presented here was designed to examine the occurrence of a genetic event, such as a postzygotic mitotic crossover, that could account for the discordance. Such a postzygotic event could affect cis-acting sequences and result in a phenotype of variable severity. We used molecular genetic methods to evaluate such an event with 94 microsatellite repeat polymorphic markers distributed on all autosomes and the X chromosome in five pairs of monozygotic twins discordant for schizophrenia. In this search, no genetic marker discordances were identified between the co-twins. The lack of a genetic difference may implicate nongenetic factors that are responsible in eliciting or suppressing the phenotype. However, the experiments performed in this study cannot eliminate the possibility that a tissue-specific mitotic crossover might have occurred in one of the discordant twins, which could not have been detected in our current study.
- Subjects :
- Adult
Chromosome Mapping
Female
Genetic Markers genetics
Humans
Male
Polymorphism, Genetic genetics
Schizophrenia diagnosis
Schizophrenia, Paranoid diagnosis
Schizophrenia, Paranoid genetics
Schizophrenia, Paranoid psychology
Twins, Monozygotic genetics
Diseases in Twins genetics
Schizophrenia genetics
Schizophrenic Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 8416016
- Full Text :
- https://doi.org/10.1016/0165-1781(93)90110-3