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Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.
- Source :
-
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1977 Jan; Vol. 16 (1), pp. 1-13. - Publication Year :
- 1977
-
Abstract
- A population of New Zealand White rabbits exhibit behavioral convulsions when given low doses of psychoactive cannabinoids of marijuana. Carbamazepine, diazepam and phenytoin were most effective in blocking these convulsions caused by delta9tetrahydrocannabinol (delta9THC). Phenobarbital and ethosuximide also blocked convulsions but only at toxic doses. Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC.
- Subjects :
- Animals
Cannabidiol pharmacology
Cannabinol pharmacology
Carbamazepine pharmacology
Diazepam pharmacology
Dose-Response Relationship, Drug
Dronabinol pharmacology
Ethosuximide pharmacology
Female
Male
Phenobarbital pharmacology
Phenytoin pharmacology
Rabbits
Time Factors
Anticonvulsants pharmacology
Dronabinol antagonists & inhibitors
Seizures chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0034-5164
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Research communications in chemical pathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 841172