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Antibody response to measles and rubella vaccine by children with HIV infection.
- Source :
-
Journal of acquired immune deficiency syndromes [J Acquir Immune Defic Syndr (1988)] 1993 Oct; Vol. 6 (10), pp. 1125-9. - Publication Year :
- 1993
-
Abstract
- To determine the immunogenicity of the measles and rubella components of the measles, mumps, and rubella virus (MMR) vaccine in human immunodeficiency virus (HIV)-infected children, we compared their response to that of uninfected controls. Sera were collected from HIV-infected patients and HIV seroreverters followed in our clinic and tested as close to 2 months post-MMR vaccination as possible. Specific IgG to both rubella and measles were measured by enzyme-linked immunosorbent assay. Of 20 children with HIV, 11 responded with adequate levels of antibody to measles. In the seroreverters, 12 of 13 responded. Of the measles responders, the median antibody level was significantly lower in the HIV-infected group than in the seroreverter group. In addition, HIV-infected responders tested at 9-15 months after vaccination demonstrated a significant decline in measles antibody levels. Although there was not a difference between the two cohorts in the proportion of patients who responded to the rubella component of the vaccine, there was a significant difference in the median antibody level of the responders of the two groups. We did not find a statistical difference in CD4 counts between responders and nonresponders. Alternate strategies will need to be established to prevent measles in HIV-infected children.
- Subjects :
- Child, Preschool
Cohort Studies
Drug Combinations
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G biosynthesis
Infant
Measles Vaccine administration & dosage
Measles-Mumps-Rubella Vaccine
Mumps Vaccine administration & dosage
Regression Analysis
Retrospective Studies
Rubella Vaccine administration & dosage
Time Factors
Vaccination
Antibodies, Viral biosynthesis
HIV Infections immunology
Measles Vaccine immunology
Rubella Vaccine immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0894-9255
- Volume :
- 6
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes
- Publication Type :
- Academic Journal
- Accession number :
- 8410669