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Physiopathological significance of thallium-201 per rectum scintigraphy in liver cirrhosis.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1993 Oct; Vol. 34 (10), pp. 1642-5. - Publication Year :
- 1993
-
Abstract
- To define the physiopathological significance of 201Tl per rectum scintigraphy, we compared results obtained using this method with direct measurement of inferior mesenteric shunting, portal pressure, liver cellular function as evaluated by the Aminopyrine Breath Test and the size of esophagogastric varices and spleen, constituting, respectively, indirect representation of azygos and splenic shunts. Results indicated that a high correlation exists between the measures of portal systemic shunt estimated by the per rectal method and those obtained by direct administration of the tracer in the inferior mesenteric artery. No correlation was observed between 201Tl per rectal results and portal pressure or with azygos and splenic shunting. Fair correlation was observed with the Aminopyrine Breath Test. This could be explained by the fact that both methods are altered in advanced liver disease. These results suggest that the 201Tl per rectal scintigraphy explores the portal systemic shunt, which depends almost exclusively on the inferior mesenteric territory. While the limited territory explored by the method constitutes, undoubtedly, a limiting factor in detection and quantitation of total portal-systemic shunt, the specific information provided by the test could be useful in defining clinical and biological profiles of cirrhotic patients with inferior mesenteric shunting.
- Subjects :
- Adult
Aged
Female
Heart diagnostic imaging
Hepatic Veins physiopathology
Humans
Liver diagnostic imaging
Liver Cirrhosis, Alcoholic physiopathology
Male
Mesenteric Artery, Inferior physiopathology
Middle Aged
Portal System physiopathology
Radionuclide Imaging
Regional Blood Flow
Spleen diagnostic imaging
Venous Pressure
Liver Cirrhosis, Alcoholic diagnostic imaging
Thallium Radioisotopes administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0161-5505
- Volume :
- 34
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 8410275