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Long-term glycemic control and neurological function in IDDM patients.
- Source :
-
Diabetes care [Diabetes Care] 1993 Sep; Vol. 16 (9), pp. 1291-3. - Publication Year :
- 1993
-
Abstract
- Objective: To examine the relationship between sensory modalities of neurological function and antecedent glycemic control in IDDM patients.<br />Research Design and Methods: Examinations were conducted on 220 IDDM patients (age at onset < 25 yr, duration < 18 yr) for the presence or absence of the right or left ankle reflex and determination of vibration perception threshold at each medial malleolus and great toe using biothesiometry. These parameters were related to the concurrent HbA1 and to a mean of serial measurements (mean HbA1) over the previous 6 yr.<br />Results: Ankle reflexes were absent in 39 (right ankle) and 41 (left ankle) patients, respectively. Mean (right + left) ankle and toe VPTs were 8.7 +/- 3.6 and 6.3 +/- 4.2 (mean +/- SD) (arbitrary units), respectively. Both the mean and concurrent HbA1 were significantly different in patients with absent ankle reflexes (11.6 +/- 1.9 and 12.2 +/- 2.8%, respectively) compared with present ankle reflexes (10.3 +/- 1.7, 10.3 +/- 2.1%) (P < 0.0001). Similarly, a present ankle reflex was related to mean HbA1 arbitrarily divided into groups < 10, 10-12, > 12% (P = 0.0009). In contrast, mean ankle VPT (8.0 +/- 2.2, 8.8 +/- 3.1, and 10.3 +/- 6.2) and toe VPT (5.5 +/- 2.2, 6.1 +/- 2.9, and 8.5 +/- 8.2) did not increase significantly with poor glycemic control (P > 0.05). Age, right ankle reflex, retinopathy, 24-h urinary albumin excretion rate, and erect systolic blood pressure were the only independent variables predicting the toe VPT using linear regression analysis.<br />Conclusions: These findings support a role for glycemic control in neurological dysfunction in IDDM patients, but also suggest that other unknown factors may be involved.
- Subjects :
- Adult
Age of Onset
Albuminuria
Analysis of Variance
Ankle Joint
Blood Pressure
Diabetic Neuropathies blood
Female
Glycated Hemoglobin analysis
Humans
Male
Reflex
Sensory Thresholds
Vibration
Blood Glucose metabolism
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 physiopathology
Diabetic Neuropathies physiopathology
Neurologic Examination
Subjects
Details
- Language :
- English
- ISSN :
- 0149-5992
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 8404434
- Full Text :
- https://doi.org/10.2337/diacare.16.9.1291