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Suppression of hyperventilation-induced attacks with infusion of atrial natriuretic peptide in patients with variant angina pectoris.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1993 Jul 15; Vol. 72 (2), pp. 128-33. - Publication Year :
- 1993
-
Abstract
- Atrial natriuretic peptide (ANP) is reported to dilate a major coronary artery in both experimental animals and humans. Spasm of a major coronary artery is the cause of variant angina pectoris and can be induced by hyperventilation. The effect of the ANP infusion on anginal attack induced by hyperventilation was studied in patients with variant angina pectoris. The study was performed in the early morning on 3 consecutive days in 11 patients with variant angina pectoris in whom the attacks were reproducibly induced by hyperventilation. On days 1 and 3 (saline solution infusion), and day 2 (ANP infusion), hyperventilation was started 14 minutes after beginning infusion of ANP (0.1 microgram/kg/min) or saline solution for 6 minutes. The attacks were induced in all 11 patients by hyperventilation on days 1 and 3. However, the attacks were not induced in any patient on day 2 of the ANP infusion. The plasma ANP level increased from 33 +/- 7 pg/ml to the peak level of 2,973 +/- 479 pg/ml (p < 0.01) at the end of the ANP infusion, and the plasma level of cyclic guanosine monophosphate (cGMP) increased from 5 +/- 1 pmol/ml to the peak level of 58 +/- 6 pmol/ml (p < 0.01) 5 minutes after the ANP infusion. The plasma levels of ANP and cGMP did not change after hyperventilation on days 1 and 3. It is concluded that the ANP infusion suppresses the attacks induced by hyperventilation in patients with variant angina pectoris, and cGMP is related to the mechanisms of suppression of the attacks.
- Subjects :
- Adult
Aged
Angina Pectoris, Variant blood
Atrial Natriuretic Factor blood
Carbon Dioxide blood
Coronary Vasospasm blood
Coronary Vasospasm etiology
Cyclic GMP blood
Electrocardiography drug effects
Female
Humans
Hydrogen-Ion Concentration
Hyperventilation blood
Hyperventilation complications
Infusions, Intravenous
Male
Middle Aged
Oxygen blood
Radioimmunoassay
Angina Pectoris, Variant complications
Atrial Natriuretic Factor administration & dosage
Coronary Vasospasm prevention & control
Hyperventilation prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 72
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 8392283
- Full Text :
- https://doi.org/10.1016/0002-9149(93)90147-5