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UV-enhanced replication of herpes simplex virus in DNA-repair competent and deficient fibroblasts.
- Source :
-
Oral surgery, oral medicine, and oral pathology [Oral Surg Oral Med Oral Pathol] 1993 May; Vol. 75 (5), pp. 602-9. - Publication Year :
- 1993
-
Abstract
- Replication of herpes simplex virus type 1 was enhanced in fibroblast cultures when cells were ultraviolet irradiated 12 to 48 hours before infection. Maximum enhancement (340% increase) occurred at exposures of 9.6 J/m2 in DNA-repair competent fibroblasts. Repair deficient xeroderma pigmentosum cells responded to lower ultraviolet exposures (1.6 to 5.6 J/m2) with lower levels of enhancement (37% to 140%). Ultraviolet irradiation of host cells before infection increased viral DNA synthesis, but did not alter the ability of the cell to adsorb virus. Prostaglandins were not shown to contribute to the process. These results suggest that ultraviolet-enhanced replication of herpes simplex virus may be associated with DNA-repair activities, and that ultraviolet-enhanced herpes simplex virus replication should be further examined for its contribution to herpes simplex virus recurrence in vivo.
- Subjects :
- DNA Replication radiation effects
DNA, Viral biosynthesis
Fibroblasts drug effects
Fibroblasts radiation effects
Herpes Simplex microbiology
Humans
Indomethacin pharmacology
Prostaglandins biosynthesis
Prostaglandins physiology
Recurrence
Simplexvirus radiation effects
Xeroderma Pigmentosum metabolism
DNA Repair
Simplexvirus physiology
Ultraviolet Rays
Virus Activation
Virus Replication radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0030-4220
- Volume :
- 75
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, and oral pathology
- Publication Type :
- Academic Journal
- Accession number :
- 8387663
- Full Text :
- https://doi.org/10.1016/0030-4220(93)90234-u