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Expression of the Epstein-Barr virus latent membrane protein in nasopharyngeal carcinoma biopsy specimens.
- Source :
-
Human pathology [Hum Pathol] 1993 Mar; Vol. 24 (3), pp. 239-42. - Publication Year :
- 1993
-
Abstract
- It has been known for some time that the Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). The tumor cells are known to harbor EBV in a latent state. Latently-infected B cells that have become growth transformed by EBV in vitro express some 10 antigens, two of which (Epstein-Barr nuclear antigen 2 [EBNA2] and the latent membrane protein [LMP]) are associated with cellular transformation. We evaluated the expression of these two EBV antigens in NPC by probing tissue sections with monoclonal antibodies. We found that EBNA2 was not expressed and that LMP was expressed in seven of nine biopsy specimens. It is therefore postulated that either there are subsets of NPC or that LMP may be involved only in certain stages of tumor formation.
- Subjects :
- Antibodies, Monoclonal
Antigens, Viral genetics
Antigens, Viral metabolism
Biopsy
Cell Transformation, Neoplastic genetics
Cell Transformation, Neoplastic pathology
China epidemiology
DNA-Binding Proteins analysis
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Epstein-Barr Virus Nuclear Antigens
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic genetics
Herpesvirus 4, Human isolation & purification
Herpesvirus 4, Human metabolism
Humans
Nasopharyngeal Neoplasms epidemiology
Nasopharyngeal Neoplasms microbiology
Viral Matrix Proteins genetics
Viral Matrix Proteins metabolism
Antigens, Viral analysis
Nasopharyngeal Neoplasms chemistry
Viral Matrix Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0046-8177
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 8384158
- Full Text :
- https://doi.org/10.1016/0046-8177(93)90032-c