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The G401 cell line, utilized for studies of chromosomal changes in Wilms' tumor, is derived from a rhabdoid tumor of the kidney.
- Source :
-
The American journal of pathology [Am J Pathol] 1993 Feb; Vol. 142 (2), pp. 375-80. - Publication Year :
- 1993
-
Abstract
- The histology, ultrastructure, and messenger RNA expression of heterotransplants derived from the G401 cell line (American Type Culture Collection) have been characterized by comparison with Wilms' and rhabdoid tumors of the kidney. This analysis illustrates that the properties of G401 heterotransplant were consistent with a rhabdoid phenotype rather than that of a Wilms' tumor. The G401 cell line has been utilized in recent experiments to demonstrate the central role of chromosome 11 in Wilms' tumor. However, the present results suggest that these experiments may be more relevant to define the involvement of chromosome 11 in rhabdoid tumor of the kidney, a malignancy distinct from Wilms' tumor. This is clinically relevant since the rhabdoid tumor of the kidney is very aggressive and associated with an extremely poor prognosis.
- Subjects :
- Animals
Histocytochemistry
Humans
Kidney Neoplasms metabolism
Kidney Neoplasms pathology
Mice
Mice, Nude
Microscopy, Electron
Neoplasm Transplantation
RNA, Neoplasm analysis
Transplantation, Heterologous
Wilms Tumor metabolism
Wilms Tumor pathology
Chromosomes, Human, Pair 11
Kidney Neoplasms genetics
Tumor Cells, Cultured
Wilms Tumor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 142
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 8382007