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HGF-SF: effects on motility and morphology of normal and tumor cells.
- Source :
-
EXS [EXS] 1993; Vol. 65, pp. 341-9. - Publication Year :
- 1993
-
Abstract
- HGF-SF is a recently discovered cytokine which has both mitogenic and motogenic effects on a wide variety of cells. We used a computerized digital imaging system to measure motility and morphology of isolated cells. In this chapter we will describe the effect of HGF-SF and of other growth factors on the velocity, area, circularity, and flatness of normal and tumor cells. We will then discuss the possible mechanism of HGF-SF induced motility and the possible role of this factor in biological and pathological processes.
- Subjects :
- Animals
Cell Line
Cell Membrane ultrastructure
Growth Substances pharmacology
Humans
Proto-Oncogene Proteins metabolism
Proto-Oncogene Proteins c-met
Proto-Oncogenes
Receptors, Cell Surface metabolism
Tumor Cells, Cultured
Cell Membrane drug effects
Cell Movement drug effects
Hepatocyte Growth Factor pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1023-294X
- Volume :
- 65
- Database :
- MEDLINE
- Journal :
- EXS
- Publication Type :
- Academic Journal
- Accession number :
- 8380741