Effect of ouabain on reinnervating mammalian skeletal muscle.

The resting membrane potential (RMP) of denervated mammalian muscle fibers increases when reinnervation occurs. This recovery of RMP is temporally associated with the return of a ouabain-sensitive fraction of the RMP. The data suggest that the activity of an electrogenic pump within the sarcolemma is, either directly or indirectly, under neurotrophic regulation.