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[Acute bilateral amaurosis caused by autoimmune optic nerve neuritis].
- Source :
-
Klinische Monatsblatter fur Augenheilkunde [Klin Monbl Augenheilkd] 1993 Jun; Vol. 202 (6), pp. 538-43. - Publication Year :
- 1993
-
Abstract
- Background: The bilateral simultaneous optic neuritis is rarely associated with multiple sclerosis. Diagnosis and prognosis have to be dealt with independently.<br />Patient: A 45-year-old woman presented with an acute bilateral simultaneous amaurosis which developed within one day with bilateral papilledema. Initially there were positive antinuclear and anticytoplasmatic antibodies and antibodies against heart and skeletal muscles. The serum titer was elevated for immunoglobulin A, lowered for complement factors C3 and C4. Antigens for polio-virus type 3 and coxsackievirus type B5 and B3 were borderline positive. An oncologic, toxic or vascular cause of the neuritis was unlikely.<br />Therapy and Course: The amaurosis lasted for 4 days. Vision improved gradually under a combined therapy with steroids, antibiotics and virostatics. Nineteen months later the vision was 20/25 OD and 20/200 OS.<br />Conclusion: The acute bilateral neuritis was probably of autoimmunological origin. Under combined antiinfectious and steroidal therapy vision improved more than expected.
- Subjects :
- Acyclovir therapeutic use
Autoantibodies analysis
Autoimmune Diseases drug therapy
Blindness drug therapy
Cardiolipins analysis
Ceftriaxone therapeutic use
Complement C3 analysis
Complement C4 analysis
Diagnosis, Differential
Drug Therapy, Combination
Female
Fluorescein Angiography
Humans
Immunoglobulin A analysis
Methylprednisolone therapeutic use
Middle Aged
Optic Neuritis drug therapy
Visual Acuity drug effects
Visual Acuity physiology
Visual Fields drug effects
Visual Fields physiology
Autoimmune Diseases immunology
Blindness immunology
Optic Neuritis immunology
Subjects
Details
- Language :
- German
- ISSN :
- 0023-2165
- Volume :
- 202
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Klinische Monatsblatter fur Augenheilkunde
- Publication Type :
- Academic Journal
- Accession number :
- 8377428
- Full Text :
- https://doi.org/10.1055/s-2008-1045641