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The oxazolidinone antibacterial agent DuP 105 does not act on cell wall biosynthesis or on a beta-lactamase.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1993 Sep 15; Vol. 195 (2), pp. 1077-80. - Publication Year :
- 1993
-
Abstract
- (S)-3-(4-Methylsulfinylphenyl)-5-(acetamidomethyl)oxazolidinone (DuP 105; 1, R = CH3SO, R' = Ac), one of a new class of antibacterial agents, is shown to be devoid of inactivation and inhibitory properties toward bacterial cell wall biosynthesis and toward a beta-lactamase. This is consistent with the idea that this class of compounds acts by a route different from that of the beta-lactam antibiotics.
- Subjects :
- Cell Wall metabolism
Kinetics
Models, Molecular
Molecular Conformation
Molecular Structure
Peptidoglycan biosynthesis
Streptococcaceae drug effects
Anti-Bacterial Agents pharmacology
Bacillus cereus enzymology
Cell Wall drug effects
Oxazoles pharmacology
Streptococcaceae metabolism
beta-Lactamases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 195
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 8373386
- Full Text :
- https://doi.org/10.1006/bbrc.1993.2154