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Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1993 Sep 01; Vol. 90 (17), pp. 7990-4. - Publication Year :
- 1993
-
Abstract
- Myelin/oligodendrocyte glycoprotein (MOG) is found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system, and it is a target antigen in experimental autoimmune encephalomyelitis and multiple sclerosis. We have isolated bovine, mouse, and rat MOG cDNA clones and shown that the developmental pattern of MOG expression in the rat central nervous system coincides with the late stages of myelination. The amino-terminal, extracellular domain of MOG has characteristics of an immunoglobulin variable domain and is 46% and 41% identical with the amino terminus of bovine butyrophilin (expressed in the lactating mammary gland) and B-G antigens of the chicken major histocompatibility complex (MHC), respectively; these proteins thus form a subset of the immunoglobulin superfamily. The homology between MOG and B-G extends beyond their structure and genetic mapping to their ability to induce strong antibody responses and has implications for the role of MOG in pathological, autoimmune conditions. We colocalized the MOG and BT genes to the human MHC on chromosome 6p21.3-p22. The mouse MOG gene was mapped to the homologous band C of chromosome 17, within the M region of the mouse MHC.
- Subjects :
- Aging metabolism
Amino Acid Sequence
Animals
Base Sequence
Brain growth & development
Cattle
Chromosome Mapping
Chromosomes, Human, Pair 6
Haplotypes genetics
Humans
In Situ Hybridization
Membrane Glycoproteins biosynthesis
Mice
Molecular Sequence Data
Myelin Proteins
Myelin Sheath metabolism
Myelin-Oligodendrocyte Glycoprotein
Oligodeoxyribonucleotides
RNA, Messenger analysis
RNA, Messenger metabolism
Rats
Sequence Homology, Amino Acid
Brain metabolism
Genes, Immunoglobulin
Major Histocompatibility Complex genetics
Membrane Glycoproteins genetics
Multigene Family
Myelin-Associated Glycoprotein
Nerve Tissue Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 90
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 8367453
- Full Text :
- https://doi.org/10.1073/pnas.90.17.7990