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Chronic methanesulfonyl fluoride enhances one-trial per day reward learning in aged rats.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 1993 Jul-Aug; Vol. 14 (4), pp. 393-5. - Publication Year :
- 1993
-
Abstract
- Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly greater speed and accuracy on a 1 trial/day discriminative reward learning task. The chronic MSF treatment resulted in a 56% decrease in brain AChE activity but no discernable locomotor side effects and no liver damage as indicated by aspartate transferase activity.
- Subjects :
- Acetylcholinesterase metabolism
Animals
Aspartate Aminotransferases blood
Brain enzymology
Cholinesterase Inhibitors toxicity
Locomotion drug effects
Male
Memory drug effects
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Sulfones toxicity
Aging psychology
Cholinesterase Inhibitors pharmacology
Discrimination Learning drug effects
Reward
Sulfones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0197-4580
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 8367021
- Full Text :
- https://doi.org/10.1016/0197-4580(93)90127-w