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Quantitative studies on aluminum deposition and its effects on neurofilament protein expression and phosphorylation, following the intraventricular administration of aluminum maltolate to adult rabbits.
- Source :
-
Neurotoxicology [Neurotoxicology] 1993 Spring; Vol. 14 (1), pp. 9-12. - Publication Year :
- 1993
-
Abstract
- The deposition of aluminum (Al) in the brain and spinal cord of adult male New Zealand white rabbits was monitored following the intraventricular administration of Al maltolate. Although decreasing concentrations of Al were observed from the injection site (approximately 10 micrograms/g dry tissue) to the lumbar cord (2.1 micrograms/g), argyrophilic tangles were present in the perikarya and proximal neurites of neurons as far distal as the lumbar and sacral cord areas. Quantitative immunoblot studies of the three neurofilament protein isoforms failed to detect changes resulting from Al maltolate treatment. Similarly no significant alterations in the total phosphate content of these cytoskeletal proteins were observed. Lastly, on Northern blots, the expression of genes encoding for the 200 kDa and 68 kDa neurofilament proteins also was unaffected by Al maltolate treatment.
- Subjects :
- Animals
Injections, Intraventricular
Lumbosacral Region
Male
Neurofilament Proteins biosynthesis
Neurofilament Proteins metabolism
Organometallic Compounds administration & dosage
Phosphorylation
Pyrones administration & dosage
Rabbits
Spinal Cord metabolism
Aluminum metabolism
Neurofilament Proteins drug effects
Organometallic Compounds pharmacokinetics
Pyrones pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0161-813X
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neurotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 8361684