[The enhancement of immune suppression by local laser irradiation in rats exposed to cyclophosphane].

The authors experimentally studied where low-energy laser radiation (LELR) can be used to enhance cyclophosphanum-induced immunodepression. Preliminary LELR of the adrenal region and cyclophosphanum, 4 mg/kg, resulted in a more profound decrease in the intensity of a primary immune response as compared to the controls received a pseudoradiation and the cytostatic in the same dosage. The findings suggest that laser radiation can be applied to the adrenal region in the clinical setting to reduce a dose of the cytostatic administered and hence adverse effects, by preserving the therapeutical level of immunodepression.