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Bequinostatins A and B new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

Authors :
Aoyama T
Kojima F
Abe F
Muraoka Y
Naganawa H
Takeuchi T
Aoyagi T
Source :
The Journal of antibiotics [J Antibiot (Tokyo)] 1993 Jun; Vol. 46 (6), pp. 914-20.
Publication Year :
1993

Abstract

New benzo[a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-producing strain Streptomyces sp. MI384-DF12. The structures of bequinostatins A and B were determined by spectral analyses to be 5,6,8,13-tetrahydro-1,6,7,9,11-pentahydroxy-8,13-dioxo-3- pentylbenzo[a]naphthacene-2-carboxylic acid and 2-decarboxybequinostatin A, respectively. Bequinostatin A showed considerable inhibitory activity against human pi class glutathione S-transferase (GST pi).

Details

Language :
English
ISSN :
0021-8820
Volume :
46
Issue :
6
Database :
MEDLINE
Journal :
The Journal of antibiotics
Publication Type :
Academic Journal
Accession number :
8344872
Full Text :
https://doi.org/10.7164/antibiotics.46.914