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Cytogenetic findings in 33 osteosarcomas.

Authors :
Mertens F
Mandahl N
Orndal C
Baldetorp B
Bauer HC
Rydholm A
Wiebe T
Willén H
Akerman M
Heim S
Source :
International journal of cancer [Int J Cancer] 1993 Aug 19; Vol. 55 (1), pp. 44-50.
Publication Year :
1993

Abstract

Thirty-three osteosarcomas (OS) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, 1 in the tetraploid range and 1 in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 OS with clonal aberrations have been reported. The recognizable structural rearrangements in these 27 tumors clustered to chromosome arms 1p, 1q, 3p, 3q, 7q, 11p, 17p and 22q. Chromosome bands 1q11, 1q21, 1q42 and 7q11 were the most frequently rearranged, and the most common numerical rearrangements were -3, -10, -13 and -15. Supernumerary ring chromosomes, in 2 tumors as the sole change, were found in all 3 parosteal OS, which is in agreement with the findings in 1 previously reported parosteal OS. The association between ring formation and parosteal morphology represents the first cytogenetic-morphologic entity among OS.

Details

Language :
English
ISSN :
0020-7136
Volume :
55
Issue :
1
Database :
MEDLINE
Journal :
International journal of cancer
Publication Type :
Academic Journal
Accession number :
8344751
Full Text :
https://doi.org/10.1002/ijc.2910550109