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Sodium hyperosmolarity of intestinal lymph causes arteriolar vasodilation in part mediated by EDRF.
- Source :
-
The American journal of physiology [Am J Physiol] 1993 Jul; Vol. 265 (1 Pt 2), pp. H323-8. - Publication Year :
- 1993
-
Abstract
- This study evaluated 1) the effect of increased submucosal lymph osmolarity on the regulation of first-order (1A) and second-order (2A) intestinal arterioles and 2) the role of endothelium-derived relaxing factor (EDRF) in hypertonic-induced vasodilation. Increasing the submucosal lymph osmolarity from 280 to 400 mosM, in increments of 30 mosM, resulted in a dose-dependent dilation of 1A and 2A. A submucosal lymph tonicity of 340 mosM, as occurs during glucose and oleic acid absorption, caused dilation of 1A (118%) and 2A (124%) equivalent to that during absorptive hyperemia. The dilation caused by 400 mosM mannitol (137%) was similar to that with 340 mosM NaCl (131%) and approximately 70% of that with 400 mosM NaCl (152%). After EDRF blockade, the responses to sodium hypertonicity decreased by about one-half; blockade reduced mannitol-induced dilation by 22%. These results indicate that sodium hypertonicity, as occurs during absorption, can play a major role in absorptive hyperemia, and about one-half of the dilation is related to a sodium-coupled release of EDRF.
- Subjects :
- Animals
Arginine analogs & derivatives
Arginine pharmacology
Arterioles physiology
Hypertonic Solutions
Male
Mannitol pharmacology
NG-Nitroarginine Methyl Ester
Osmolar Concentration
Rats
Rats, Sprague-Dawley
Saline Solution, Hypertonic pharmacology
Intestinal Mucosa metabolism
Intestines blood supply
Lymph metabolism
Nitric Oxide physiology
Sodium metabolism
Vasodilation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 265
- Issue :
- 1 Pt 2
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 8342649
- Full Text :
- https://doi.org/10.1152/ajpheart.1993.265.1.H323