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Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1993 Jul 15; Vol. 90 (14), pp. 6439-43. - Publication Year :
- 1993
-
Abstract
- Development and survival of neurons in the central nervous system are dependent on the activity of a variety of endogenous neurotrophic agents. Using combined isotopic and nonisotopic in situ hybridization histochemistry, we have found that subsets of neurons within the developing forebrain coexpress the mRNAs for both neurotrophins (nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3) and their receptors (p75NGFR, TrkA, and TrkB). The colocalization of mRNA for neurotrophin receptors and their ligands in presumptive neurotrophin target neurons suggests the potential for autocrine and paracrine mechanisms of action during development. Such mechanisms may ensure the onset of differentiation and survival of specific subsets of neurons prior to and following target innervation.
- Subjects :
- Animals
Brain-Derived Neurotrophic Factor
In Situ Hybridization
Membrane Proteins isolation & purification
Mice
Mice, Inbred Strains embryology
Nerve Tissue Proteins isolation & purification
Neurotrophin 3
Proto-Oncogene Proteins isolation & purification
Rats
Rats, Inbred Strains embryology
Receptor, Ciliary Neurotrophic Factor
Receptor, trkA
Brain embryology
Nerve Growth Factors isolation & purification
Neurons chemistry
RNA, Messenger isolation & purification
Receptors, Nerve Growth Factor isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 90
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 8341652
- Full Text :
- https://doi.org/10.1073/pnas.90.14.6439