Amino acids and peptides. XVIII. Synthetic peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.

Authors :: Kawasaki K
Miyano M
Hirase K
Iwamoto M
Source :: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1993 May; Vol. 41 (5), pp. 975-7.
Publication Year :: 1993
Abstract: Peptide analogs of the N-terminal portion of fibrin alpha-chain were prepared and their inhibitory effects on fibrinogen/thrombin clotting were examined. Of the synthetic peptides, H-Gly-Pro-Arg-Pro-Pro-NH2 exhibited the most potent inhibitory effect.

Subjects :: Amino Acid Sequence
Fibrin chemical synthesis
Fibrin pharmacology
Fibrinogen antagonists & inhibitors
Molecular Sequence Data
Oligopeptides chemistry
Structure-Activity Relationship
Thrombin antagonists & inhibitors
Anticoagulants chemical synthesis
Anticoagulants pharmacology
Fibrin analogs & derivatives
Oligopeptides chemical synthesis
Oligopeptides pharmacology

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